the ‘Fully automated postoperative ventilation in cardiac surgery patients’ (POSITiVE) singlecenter randomized clinical trial determined the effect of automated ventilation by means of INTELLiVENT–ASV versus ventilation that was not automated on the quality of breathing in 220 patients after cardiac surgery

POSITiVE is registered at clinicaltrials (NCT03180203); the primary analysis was published in British Journal of Anaesthesiology (2020; 125:739), a secondary analysis was published in Intensive Crit Care Nurs (2025; 89:103963)

‘Postoperative INTELLiVENT–adaptive support ventilation in cardiac surgery patients’ (POSITiVE II), an international multicenter randomized clinical trial, is the successor of POSITiVE

the database of POSITiVE is not available for secondary analyses

the ‘Closed–loop ventilation using sidestream versus mainstream capnography for automated adjustment of alveolar minute ventilation’ (INTELLiSTREAM) singlecenter randomized clinical trial determined the effect of automated that uses sidestream versus mainstream capnography on the quality of breathing in 73 patients after cardiac surgery

INTELLiSTREAM is registered at clinicaltrials (NCT04599491); the primary analysis was published in PLoS One (2023; 18:0289412)

seondary analyses focus on alarm incidences and patient ventilator asynchronies

connect with Marcus Schultz for secondary analyses of the INTELLiSTREAM database

the ‘The effect of closed–loop versus conventional ventilation on mechanical power’ (INTELLiPOWER) international multicenter randomized crossover trial determined the effect of INTELLiVENT–ASV versus conventional ventilation on the mechanical power of ventilation in 96 critically ill patients receiving mechanical ventilation

INTELLiPOWER is registered at clinicaltrials (NCT04827927); the primary analysis was published in PLoS One (2024; 19:0307155)

the database of INTELLiPOWER contains high-granular data, enabling the detection of patient–ventilator asynchrony – a posthoc analysis is currently being performed

in other analyses, we will compare various power equations and focus on the effects of automated ventilation on alarm incidences

the ‘Effect of automated closed–loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients’ (ACTiVE) international multicenter randomized clinical trial determines the effect of INTELLiVENT–ASV versus conventional ventilation on the number of ventilator free days at day 28 in 1200 critically ill patients receiving mechanical ventilation

ACTiVE is registered at clinicaltrials (NCT04593810); the study protocol was published in TRIALS (2022; 23:348)

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the ‘Postoperative INTELLiVENT–adaptive support ventilation in cardiac surgery patients’ (POSITiVE II) international multicenter randomized clinical trial determines the effect of automated ventilation by means of INTELLiVENT–ASV versus ventilation that is not automated on the quality of breathing in 328 patients after cardiac surgery

POSITiVE II is registered at clinicaltrials (NCT06178510); the study protocol was published in TRIALS (2024; 25:449)

POSITiVE II is the successor of the ‘Fully automated postoperative ventilation in cardiac surgery patients’ (POSITiVE) singlecenter randomized clinical trial

connect with the international coordinator for questions

the ‘The effect of closed–loop versus conventional ventilation on oxygen and PEEP settings’ (INTELLiOXY) is a substudy of ‘The effect of closed–loop versus conventional ventilation on mechanical power’ (INTELLiPOWER) international multicenter randomized crossover trial, and determined the effect of INTELLiVENT–ASV versus conventional ventilation on oxygen and PEEP titrations, and alarms related to oxygen in a subset of patients in whom granular, breath–by–breath data are collected

the parent study was registered at clinicaltrials (NCT04827927); the primary analysis was published in Journal of Clinical Medicine (2025; 14:41)

more information can be found above, in the description of the parent INTELLiPOWER study

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the ‘Does Automated Closed–Loop Ventilation Reduce the DRiving Pressure Levels in Patients With ARDS' (AiRDRoP) randomized crossover clinical trial determined the effect of INTELLiVENT–ASV versus conventional ventilation on transpulmonary and respiratory system ΔP in invasively ventilated ARDS patients

AiRDRoP is registered at clinicaltrials (NCT03211494); the primary analysis was published in Intensive Care Medicine Experimental (2023; 11:42)

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the ‘Brain Recovery with Automated Ventilation’ (BRAVE) crossover clinical trial compared INTELLiVENT–ASV with conventional ventilation in patients with acute brain injury, focusing on both brain– and lung–protection

BRAVE is registered at clinicaltrials (NCT06367816); the primary analysis will be ready soon

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