the ‘Epidemiological characteristics, practice of ventilation, and clinical outcomes in patients at risk of ARDS’ (PRoVENT) was an international multicenter observational prospective study undertaken at 119 ICUs in 16 countries worldwide

PRoVENT is registered at clinicaltrials (NCT01868321); the primary analysis was published in THE LANCET Respiratory Medicine (2016; 4:882)

the database of PRoVENT is harmonized with those from other observational studies, including PROVENT–iMiC, ERICC and LUNG SAFE in a pooled database

connect with Ary Serpa Neto or David van Meenen for secondary analyses of the PRoVENT database

the  ‘PRactice of VENTilation in Middle–income Countries’ (PRoVENT–iMiC) was an international multicenter observational study undertaken in approximately 60 ICUs in 11 Asian countries

PRoVENT–iMiC is registered at clinicaltrials (NCT03188770); the study protocol was published in British Medical Journal (2018; 8:e020841); the primary analysis was published in American Journal of Tropical Medicine & Hygiene (2021; 104:1022)

the database of PRoVENT–iMiC is harmonized with those from other observational studies, including PROVENT, the 'Clinical outcomes of patients requiring ventilatory support in Brazilian ICUs' (ERICC) and 'Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure' (LUNG SAFE) into a pooled database named PRoPERLy

connect with Luigi Pisani or David van Meenen for secondary analyses of the PRoVENT–iMiC database

the ‘Local Assessment of Management of Burn Patients’ (LAMINAR) was an international multicenter observational study in burn patients

LAMINAR is registered at clinicaltrials (NCT02312869); the primary analysis was published in Burns & Trauma (2021; 9:34)

the database of LAMINAR is not harmonized with other observational studies, and not available for secondary analyses

PROVE Network supported the  ‘Extubation Strategies in Neurocritical Care Patients’ (ENIO), an international multicenter observational study undertaken in 73 ICUs in 18 countries

ENIO is registered at clinicaltrials (NCT03400904); the study protocol was published in Annals of Translational Medicine (2020; 8:503); the primary analysis was published in Intensive Care Medicine (2022; 48:1539)

the database of ENIO  is harmonized with those from PROVENT and PRoVENT–iMiC' into a pooled database named PRIME

the database of the soon to start ‘Extubation Strategies in Neurocritical Care Patients in Middle–income Countries’ (ENIO–iMiC) will be mergable with ENIO

connect with Raphael Cinotti and Chiara Robba for secondary analyses of the ENIO database

'Ventilatory Support in Pediatric Intensive Care Unit Patients' (VESPer) assessed ventilatory support settings in critically ill pediatric patients across European centers, and explored ventilatory support variables and parameters amongst various groups of critically ill patients receiving invasive or noninvasive ventilation

VESPer served as a pilot for PRoVENT–PED, an international multicenter prospective observational study (registered at clinicaltrials NCT06220825)

connect with Martin Kneyber or David van Meenen for secondary analyses of the VESPer database

the ‘PRactice of VENTilation in PEDiatric patients’ (PRoVENT–PED) is an international multicenter prospective observational study, planned to capture data on epidemiology, ventilation characteristics, and outcomes in critically ill children

PRoVENT–PED is registered at clinicaltrials (NCT06220825); the study protocol will be made available soon (pending)

the study has started per March 1, 2024

PRoVENT–PED  is designed so that its database can be harmonized and pooled with PRoVENT and PRoVENT 2+.

contact us in case you have questions

the ‘REhabilitation and Physiotherapy in critically ill patients and association with Ventilator Free Days, Outcome, and Quality Of Life’ (REPOrt) is a new international multicenter observational study focusing on practice of physiotherapy and ventilation in critically ill ventilated patients

REPOrt will be registered at clinicaltrials (pending); the study protocol will be made available (pending)

the study protocol is currently under ethical consideration; more information can be found at the REPOrt website

REPOrt is designed so that its database can be harmonized and pooled with those from PRoVENT and PRoVENT 2+

contact us in case you have questions

the ‘Update on the PRactice of mechanical VENTilation in non-ARDS patients’ (PRoVENT 2+) is a new international multicenter prospective observational study, planned to capture data on epidemiology, ventilation characteristics, and outcomes in critically ill patients

PRoVENT 2+ will be registered at clinicaltrials (pending); the study protocol will be made available (pending)

the study protocol is currently under ethical consideration

PRoVENT 2+ is the succesor of PRoVENT, and is designed so that their databases can be harmonized and pooled

contact us in case you have questions