the  ‘PRactice of VENTilation in Middle–income Countries’ (PRoVENT–iMiC) was an international multicenter observational study undertaken in approximately 60 ICUs in 11 Asian countries

PRoVENT–iMiC is registered at clinicaltrials (NCT03188770); the study protocol was published in British Medical Journal (2018; 8:e020841); the primary analysis was published in American Journal of Tropical Medicine & Hygiene (2021; 104:1022)

the database of PRoVENT–iMiC is harmonized with those from other observational studies, including PROVENT, the 'Clinical outcomes of patients requiring ventilatory support in Brazilian ICUs' (ERICC) and 'Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure' (LUNG SAFE)

connect with Luigi Pisani or David van Meenen for secondary analyses of the PRoVENT–iMiC database

PROVE Network will soon start the  ‘Extubation Strategies in Neurocritical Care Patients in Middle–income Countries’ (ENIO–iMiC), an international multicenter observational study in (low and) middle–income countries

ENIO–iMiC will be registered at clinicaltrials (pending); the study protocol will be pre–published (pending)

the database of ENIO–iMiC will be harmonized with the database of ENIO

connect with Marcus Schultz or Gentle Shrestha for questions

the ‘PRactice of VENTilation in PEDiatric patients’ (PRoVENT–PED) is a new international multicenter prospective observational study, planned to capture data on epidemiology, ventilation characteristics, and outcomes in critically ill children

investigators from low– and middle–income countries are encouraged to partake in this global study, spanning multiple years and comprising various episodes

PRoVENT–PED is registered at clinicaltrials (NCT06220825); the study protocol will be made available (pending)

the study protocol is currently under ethical consideration at various locations

PRoVENT–PED  is designed so that its database can be harmonized and pooled with PRoVENT and PRoVENT 2+.

contact us in case you have questions

the ‘Update on the PRactice of mechanical VENTilation in non-ARDS patients’ (PRoVENT 2+) is a new international multicenter prospective observational study, planned to capture data on epidemiology, ventilation characteristics, and outcomes in critically ill patients

investigators from low and middle–income countries are welcome to participate in this worldwide study

PRoVENT 2+ will be registered at clinicaltrials (pending); the study protocol will be made available (pending)

the study protocol is currently under ethical consideration

PRoVENT 2+ is the succesor of PRoVENT, and is designed so that their databases can be harmonized and pooled

contact us in case you have questions

the ‘PRactice of VENTilation in Patients With ARDS Due to COVID–19 vs Pneumonia’ (PRoVENT–COP) is a harmonized pooled database of 4 national studies of ventilation in COVID patients (PRoVENT–COVID, EPICCoV, CIBERESUCICOVID, and SATI–COVID–19) and 2 multicenter observational studies of ventilation in non-COVID patients (ERICC and LUNG SAFE)

the pooled databases originate from high–income countries as well as from low and middle–income countries 

PRoVENT–COP is registered at clinicaltrials (NCT05650957); the first analyses are currently under review

connect with David van Meenen  for secondary analyses of the PRoVENT–COP database; all analyses need approval from the investigators of the 6 individual studies

a posthoc analyis of the  ‘Extubation Strategies in Neurocritical Care Patients’ (ENIO), an international multicenter observational study undertaken in 73 ICUs in 18 countries, characterized the impact of country income level on ventilation strategies and outcomes in a diverse population of neurocritical care patients

patients were classified by country income level according to World Bank definitions: 77% were from HICs, and 23% from MICs

ENIO is registered at clinicaltrials (NCT03400904); the study protocol was published in Annals of Translational Medicine (2020; 8:503); this posthoc  analysis will be published soon in Neurocritical Care (pending)

connect with Raphael Cinotti and Chiara Robba for secondary analyses of the ENIO database