‘Practice of Fluid and Vasopressor Therapy in Critically Ill Invasively Ventilated Patients’ (PRoFLUID) is an international, multicenter, observational cohort study in critically ill adult patients that are invasively ventilated for more than 24 hours

PRoFLUID will provide useful insights into the practice of fluid and vasopressor therapy in invasively ventilated critically ill patients; it also allows to determine whether geo–economic differences in management of intravenous fluid and vasopressor therapy exist

PRoFLUID is registered at clinicaltrials (NCT05968066); the study protocol was published in Annals of Translational Medicine (2024; 12:92); the primary analysis will be performed soon

connect with Siebe Blok or Marcus Schultz for information on this study

‘Effect of lung ultrasound-guided fluid deresuscitation on duration of ventilation in intensive care unit patients’ (CONFIDENCE) is an international multicenter randomized clinical trial in adult critically ill patients that are expected to be invasively ventilated for at least 24 hours

patients assigned to the intervention will receive daily LUS with fluid balance recommendations; subjects in the control arm are deresuscitated at the physician's discretion without the use of LUS; the primary endpoint is the number of ventilator–free days and being alive at day 28

CONFIDENCE is registered at clinicaltrials (NCT05188092); the study protocol was published in TRIALS (2023; 24:226)

connect with Siebe Blok or Marcus Schultz for information on this study

this was a preplanned secondary analysis of the ‘Low versus Conventional tidal volumes during one–lung ventilation for minimally invasive oesophagectomy trial’ (LoCo), a singlecenter randomized clinical trial that compared intraoperative protective ventilation with conventional ventilation during esophagectomy

this secondary analysis focussed on the effects on fluid management and vasopressor use

LoCo is registered at Netherlands Trial Register (NTR 4391); this secondary analysis was published in European Journal of Anaesthesiology (2022; 39:841)

connect with Marcus Schultz for secondary analyses of the LoCo database

this was a preplanned secondary analysis of the ‘PRactice of VENTilation in patients with COVID–19’ (PRoVENT–COVID), a nationwide multicenter observational study undertaken at 22 Dutch ICUs, including 1022 patients from the first wave of the national outbreak

this secondary analysis studied the association between early cumulative fluid balance and successful liberation from invasive ventilation

PRoVENT–COVID is registered at clinicaltrials (NCT04346342); the study protocol was published in Annals of Translational Medicine (2020; 8;1251); this secondary analysis was published in Critical Care (2022; 26:157)

connect with Marcus Schultz or Frederique Paulus for secondary analyses of the PRoVENT–COVID database