the ‘Re–evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery’ (REPEAT) database includes the harmonized data from 3 large RCTs, the ‘PROtective Ventilation using HIgh versus LOw PEEP trial’ (PROVHILO), the ‘individualized PeRioperative Open-lung Ventilation trial’ (iPROVE), and the ‘Protective intraoperative ventilation with higher versus lower levels of PEEP in obese patients trial’ (PROBESE)

REPEAT is registered at clinicaltrials (NCT03937375) and its protocol was published in the Revista Española de Anestesioloía y Reanimación (English edition) (2020; 67:76)

ideally suited for analyzing the effects of PEEP across patient groups

analyses of REPEAT were published in British Journal of Anaesthesia (2022; 128:1040), Anesthesiology (2024; 142:72), European Journal of Anaesthesiology (2025; 42:340), and in Anaesthesia (2025; in press)

connect with Ary Serpa Neto, David van Meenen or Guido Mazzinari for secondary analyses of the REPEAT database

the ‘Laparoscopic vs Robotic–assisted abdominal surgery' (LAPRAS) database includes the harmonized data from abdominal surgery patients in 2 obervational studies of ventilation, ‘Local ASsessment ofVEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS), and ‘Assessment of Ventilation during general AnesThesia for Robotic surgery' (AVATaR)

LapRas is registered at clinicaltrials (NCT06234774) and its protocol was published in Revista Española de Anestesiología y Reanimación (Spanish edition) (2024; 71:592)

ideally suited for analyzing ventilation management across patient undergoing open versus closed abdominal surgery

the first analysis of LapRas is submitted for publication in a peer–reviewed journal

connect with  Lorenzo Ball or Guido Mazzinari for secondary analyses of the LapRas database

the ‘without ARDS’ (wizARDS) database, includes the harmonised data from 3 large RCTs, the ‘Effectiveness of routine nebulization of mucolytic agents and bronchodilating drugs in intubated and mechanically ventilated intensive care unit patients’ (NEBULAE), the ‘PRotective VENTilation in patients without ARDS at start of ventilation’ (PReVENT), and the ‘Restricted versus Liberal PEEP in patients without the ARDS’ (RELAx)

analyses of wizARDS were published in European Journal of Anaesthesiology (2023; 40:21) and Anaesthesia (2025; 80:533)

ideally suited for analyzing mechanical ventilation across groups of patients without ARDS

connect with David van Meenen or Frederique Paulus for secondary analyses of the wizARDS database

the ‘PRoVENT, PRoVENT–iMiC, ERICC and LUNG SAFE' (PRoPERLy) database includes the harmonized data from 4 obervational studies of ventilation, the ‘Epidemiological characteristics, practice of ventilation, and clinical outcomes in patients at risk of ARDS’ (PRoVENT), ‘PRactice of VENTilation in Middle–income Countries' (PRoVENT–iMiC), ‘Clinical outcomes of patients requiring ventilatory support in Brazilian ICUs’ (ERICC) and ‘Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure’ (LUNG SAFE)

analyses of PRoPERLy were published in THE LANCET Global Health (2022; 10:e227) and Journal of Critical Care (2024; 81:154531)

ideally suited for analyzing mechanical ventilation across groups of patients without ARDS

connect with Simon Corrado Serafini or David van Meenen for secondary analyses of the PRoPERLy database; all analyses need approval from the investigators of the individual studies

as the ‘PRoVENT, PRoVENT–iMiC, ERICC and LUNG SAFE' databases also include patients with ARDS, we have decided to create a new harmonized and pooled dataset, named PRoPERLy II

PRoPERLy II enables analyses that includes patients with ARDS, as well as comparisons between patients with ARDS, patienst at risk of ARDS, and patients without ARDS

PRoPERLy II is registered at clinicaltrials (NCT06589427); the first analysis plan of PRoPERLy II was published in Critical Care Science (2025; in press)

ideally suited for analyzing mechanical ventilation across groups of patients with or without ARDS

connect with Simon Corrado Serafini or Guido Mazzinari for secondary analyses of the PRoPERLy II database; all analyses need approval from the investigators of the individual studies

the ‘PRactice of VENTilation in Patients with ARDS due to COVID–19 vs Pneumonia’ (PRoVENT–COP) is a harmonized pooled database of 4 national studies of ventilation in COVID patients (PRoVENT–COVID, EPICCoV, CIBERESUCICOVID, and SATI–COVID–19) and 2 multicenter observational studies of ventilation in non-COVID patients (ERICC and LUNG SAFE)

PRoVENT–COP is registered at clinicaltrials (NCT05650957); the first analyses were published in Respiratory Research (2024; 25:312), the American Journal of Tropical Medicine & Hygiene (2025; 112:875) and the Journal of Clinical Medicine (2025; in press)

ideally suited for analyzing mechanical ventilation across COVID–19 ARDS patients 

connect with David van Meenen  for secondary analyses of the PRoVENT–COP database; all analyses need approval from the investigators of the 6 individual studies

the database of PRoVENT–COVID is harmonized and merged with the database of PRoAcT–COVID in a pooled database named ‘PRactice of Ventilation and Adjunctive Therapies in COVID–19 Patients’ (PRoVAcT)

PRoVAcT is registered at clinicaltrials (NCT05954351); the first analysis was published in Journal of Critical Care (2024; 83:154854), CHEST Critical Care (2025; in press) with more to follow

ideally suited for analyzing mechanical ventilation across COVID–19 ARDS patients 

connect with Frederique Paulus or Marcus Schultz for secondary analyses of the PRoVAcT database