the ‘PRactice of VENTilation in patients with COVID–19’ (PRoVENT–COVID) was a nationwide multicenter observational study undertaken at 22 Dutch ICUs, including 1022 patients from the first wave of the national outbreak

PRoVENT–COVID is registered at clinicaltrials (NCT04346342); the study protocol was published in Annals of Translational Medicine (2020; 8;1251); two main analyses were published in THE LANCET Respiratory Medicine (2021; 9:139 and 2021; 12:1377)

you can visit the dedicated website of PRoVENT–COVID to access all 18 published analyses to date

connect with Marcus Schultz or Frederique Paulus for secondary analyses of the PRoVENT–COVID database

the ‘PRactice of Adjunctive Treatments in intensive care unit patients with COVID–19’ (PRoAcT–COVID) was a nationwide multicenter observational study in the second wave of the national outbreak in the Netherlands

PRoAcT–COVID is registered at clinicaltrials (NCT04719182); the study protocol was published in Annals of Translational Medicine (2021; 9:813); several analyses have been published, including in Journal of Clinical Medicine (2022; 11:6988) and in Journal of Critical Care (2024; 83:254853)

you can visit the dedicated website of PRoAcT–COVID to access additional analyses

connect with Marcus Schultz or Frederique Paulus for secondary analyses of PRoAcT–COVID

the ‘PRactice of VENTilation in Patients with ARDS due to COVID–19 vs Pneumonia’ (PRoVENT–COP) is a harmonized pooled database of 4 national studies of ventilation in COVID patients (PRoVENT–COVID, EPICCoV, CIBERESUCICOVID, and SATI–COVID–19) and 2 multicenter observational studies of ventilation in non–COVID patients (ERICC and LUNG SAFE)

PRoVENT–COP is registered at clinicaltrials (NCT05650957); the first analyses were published in Respiratory Research (2024; 25:312), the American Journal of Tropical Medicine & Hygiene (2025; 112:875), the Journal of Thoracic Disease (2025; in press), and in Critical Care Science (2025; in press)

connect with David van Meenen  for secondary analyses of the PRoVENT–COP database; all analyses need approval from the investigators of the 6 individual studies

the database of PRoVENT–COVID is harmonized and merged with the database of PRoAcT–COVID in a pooled database named ‘PRactice of Ventilation and Adjunctive Therapies in COVID–19 Patients’ (PRoVAcT)

PRoVaCT is registered at clinicaltrials (NCT05954351); the first analysis was published in Journal of Critical Care (2024; 83:154854) with more to follow

connect with Frederique Paulus or Marcus Schultz for secondary analyses of the PRoVAcT database