this systematic review, published in Expert Review of Respiratory Medicine (2016; 10:1123), showed a wide variability among different centers in the treatment strategies and respiratory management of neurocritical care patients

it highlights the need for shared diagnostics and therapeutic studies, in order to improve the outcome of these patients

the ‘Local ASsessment ofVEntilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) worldwide multicenter observational study in 10520 patients in 146 countries described the epidemiology, ventilation practive and outcome of patients receiving intraoperative ventilation under general anesthesia for surgery

LAS VEGAS is registered at clinicaltrials (NCT01601223)

the findings of this secondary analysis, focusing on intraoperative ventilation in neurosurgical patients, was published in BMC Anaesthesiology  (2020; 20:73)

connect with Sabrine Hemmes or Lorenzo Ball for secondary analyses of the LAS VEGAS database

PROVE Network supported the  ‘Extubation Strategies in Neurocritical Care Patients’ (ENIO), an international multicenter observational study undertaken in 73 ICUs in 18 countries

ENIO is registered at clinicaltrials (NCT03400904); the study protocol was published in Annals of Translational Medicine (2020; 8:503); the primary analysis was published in Intensive Care Medicine (2022; 48:1539)

several secondary analysis have been performed, and published in various journals like Critical Care (2023; 27:156), American Journal of Respiratory and Critical Care Medicine (2023; 208:270), Neurocritical Care (2024; 40:515), and Critical Care Medicine (2024; 52:1258)

connect with Raphael Cinotti and Chiara Robba for secondary analyses of the ENIO database

the ‘Brain Recovery with Automated Ventilation’ (BRAVE) crossover clinical trial compared INTELLiVENT–ASV with conventional ventilation in patients with acute brain injury, focusing on both brain– and lung–protection

BRAVE is registered at clinicaltrials (NCT06367816); the primary analysis will be ready soon

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