history

the PROVE Network, established in 2014 by Prof. Paolo Pelosi, Prof. Marcelo Gama de Abreu, Prof. Marcus Schultz, Dr. Sabrine Hemmes, and Prof. Ary Serpa Neto, conducts impactful multicenter clinical studies in ventilation; among the pivotal investigations that laid the foundation for the network were the PROVHILO and LAS VEGAS studies, with Prof. Edda Tschernko as one of the pioneers of PROVHILO, playing a key role in their development and execution 

our research explores novel strategies to enhance patient care and safety in operating rooms (OR) and intensive care units (ICU)

led by esteemed professionals, the network comprises dedicated sections for randomized clinical trials (RCTs), observational studies, and secondary/meta–analyses; Dr. Chiara Robba and Dr. Denise Battaglini lead the RCT section, Dr. Sabrine Hemmes and Dr. Lorenzo Ball oversee observational studies, Prof. Ary Serpa Neto, supported by Dr. Guido Mazzinari and Dr. David van Meenen, heads the section for secondary/meta–analyses, Prof. Frederique Paulus supervises the COVID–19 projects, Dr. Laura Buiteman coordinates the studies of closed–loop ventilation, Dr. Prashant Nasa guides Delphi's, Dr. Silvia De Rosa and Dr. Martin Bernardi lead analyses involving kidney injury, Prof. Juliana Ferreira overviews the patient–ventilator asynchrony projects, and Prof. Edda Tschernko coordinates the studies in cardiac surgery patients

in addition, the PROVE Network is also involved in artificial intelligence (AI) and preclinical projects at various specialized laboratories worldwide, and this work is managed by Dr. Robert Huhle, Dr. Martin Scharffenberg, Dr. Jakob Wittenstein, Prof. Patricia Rocco and Prof. Edda Tschernko

true worldwide collaborations

discover our global network of research centers across 6 continents, actively engaged in groundbreaking clinical investigations and innovative preclinical studies

join our collaborative spirit that transcends borders, fueling continuous advancements

high–quality research

the PROVE Network conducts a broad range of research, from gathering expert consensus through surveys and Delphi studies, to evaluating real–world outcomes with observational studies, testing interventions via randomized clinical trials, and synthesizing evidence with systematic reviews and meta–analyses to inform clinical practice

the PROVE Network performs high–quality research and initiates research projects based on ideas from researchers within and from outside the network

in every project an original hypothesis is tested, using an adequate study design and a sufficient number of patients, and PROVE Network–initiated studies follow a strict action plan

promoting gender and age balance

PROVE Network is committed to fostering diversity and inclusivity in all aspects of our research; we actively promote gender and age balance among our collaborators, coordinators, and investigators, ensuring that our research reflects a wide range of perspectives and experiences

by prioritizing inclusivity, we aim to create opportunities for all individuals, ensuring that both females and males, as well as younger and more experienced colleagues, can contribute and learn from one another

published work

PROVE Network investigators publish their work in peer–reviewed journals; an overview of published work can be found at PubMed

more than 20 academic theses have been written and defended; in the coming 2 years, 14 additional theses will be completed

in the legacy of Paolo Pelosi

we greatly miss our mentor, colleague, and close friend, Paolo, who was a real mastermind in uniting colleagues all over the world for the sake of improving the care of patients; in the legacy of Paolo, we will continue his mission by bringing people together, working together, and will not forget the joy and fun while doing this all