the ‘Fully automated postoperative ventilation in cardiac surgery patients’ (POSITiVE) singlecenter randomized clinical trial determined the effect of automated ventilation by means of INTELLiVENT–ASV versus ventilation that was not automated on the quality of breathing in 220 patients after cardiac surgery

POSITiVE is registered at clinicaltrials (NCT03180203); the primary analysis was published in British Journal of Anaesthesiology (2020; 125:739), a secondary analysis was published in Intensive Crit Care Nurs (2025; 89:103963)

‘Postoperative INTELLiVENT–adaptive support ventilation in cardiac surgery patients’ (POSITiVE II), an international multicenter randomized clinical trial, is the successor of POSITiVE

the database of POSITiVE is not available for secondary analyses

the ‘Postoperative INTELLiVENT–adaptive support ventilation in cardiac surgery patients’ (POSITiVE II) international multicenter randomized clinical trial determines the effect of automated ventilation by means of INTELLiVENT–ASV versus ventilation that is not automated on the quality of breathing in 328 patients after cardiac surgery

POSITiVE II is registered at clinicaltrials (NCT06178510); the study protocol was published in TRIALS (2024; 25:449)

POSITiVE II is the successor of the ‘Fully automated postoperative ventilation in cardiac surgery patients’ (POSITiVE) singlecenter randomized clinical trial

connect with the international coordinator for questions

the ‘Closed–loop ventilation using sidestream versus mainstream capnography for automated adjustment of alveolar minute ventilation’ (INTELLiSTREAM) singlecenter randomized clinical trial determined the effect of automated that uses sidestream versus mainstream capnography on the quality of breathing in 73 patients after cardiac surgery

INTELLiSTREAM is registered at clinicaltrials (NCT04599491); the primary analysis was published in PLoS One (2023; 18:0289412)

seondary analyses focus on alarm incidences and patient ventilator asynchronies

connect with Marcus Schultz for secondary analyses of the INTELLiSTREAM database

using a mixed Delphi methodology, expert consensus statements are being developed regarding which patient–ventilator asynchronies can be detected using ventilator waveforms alone, and their associated risks for worse outcomes

a hierarchical tree will be developed based on the severity of these associations with outcomes

an international panel scored these statements over several rounds; the Delphi process is nearly completed

connect with Laura Buiteman or Prashant Nasa  for information on this Delphi