postoperative pulmonary complications
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connect with Marcus Schultz for inquiries about these projects
[1] EPCO
the European Society of Anaesthesiology (ESA) and the European Society of Intensive Care Medicine (ESICM) therefore established a joint task force to evaluate the literature and create standards for the definition and use of outcome measures in clinical effectiveness research in perioperative medicine
'European Perioperative Clinical Outcome' (EPCO) focused on the assessment and characterization of PPCs using standardized outcome definitions, including respiratory infection, respiratory failure, pleural effusion, atelectasis, pneumothorax, bronchospasm, and aspiration pneumonitis
the EPCO definitions have been published in European Journal of Anaesthesiology (2015; 32:88), and have since been used in many studies
connect with Marcus Schultz for further information on the EPCO project
[2] PrECiSIOn
this Delphi, named 'Postoperative pulmonary complications - Evaluation for Consensus on StandardIzed Outcomes' (PrECiSIOn) will identify current insights into how postoperative pulmonary complications should be defined and graded
it will involve anesthesiologists/intensivists, surgeons, and respiratory therapists from both high-income and low– and middle–income countries, as well as the involvement of patients and health economists
the Delphi is registered at clinicaltrials (NCT06916598); the study protocol was published in British Medical Journal Open (2025; 15:e103888); the primary analysis will be published soon in Lancet Respiratory Medicine (2026; in press)
connect with Sabrine Hemmes or Prashant Nasa for information on this Delphi
[3] REPEAT meets PrECiSIOn
'REPEAT Meets PrECiSIOn' evaluates the reproducibility and applicability of the PrECiSIOn framework for defining PPC, including their incidence and severity according to the complete PrECiSIOn definition and the minimal PrECiSIOn core set across predefined patient populations in the REPEAT databases
the analysis will also assess clinically relevant subgroups according to age, sex, obesity, surgical approach, and ARISCAT score, and will provide population–specific estimates to support the design and sample–size calculations of future perioperative studies
connect with Timur Yurttas for this project, also when you want to do a sample–size calculation in REPEAT or REPEAT II
connect with us if you want to do a posthoc analysis using one of these databases
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